Aihara K, Nishi Y, Hatano S, Kihara M, Ohta M, Sakoda K, Uozumi T, Usui T
J Pediatr Gastroenterol Nutr. 1985 Aug;4(4):610-5. doi: 10.1097/00005176-198508000-00020.
This study was designed to evaluate trace metal metabolism in patients with known abnormalities of human growth hormone (hGH). The mean concentration of zinc in plasma and urine decreased in patients with hGH deficiency after hGH injection, whereas, after adenomectomy, in patients with acromegaly, zinc increased in plasma, remained the same in erythrocytes, and decreased in urine. There was a negative correlation between plasma zinc and serum hGH levels and a positive correlation between urinary zinc excretion and serum hGH levels in acromegaly. In hGH deficiency, the copper content remained unchanged in plasma and erythrocytes and rose in urine after treatment; however, in acromegaly, the copper content increased in plasma and remained unchanged in erythrocytes and urine after surgery. The mean concentration of erythrocyte manganese did not change significantly after treatment in patients with hGH deficiency or acromegaly, but the pre-hGH treatment level of erythrocyte manganese in hGH deficiency was lower than in the controls. Plasma selenium concentrations were decreased in hGH deficiency and increased in acromegaly patients after therapy. These results suggest that hGH affects the metabolism of zinc, copper, manganese, and selenium.
本研究旨在评估已知人类生长激素（hGH）异常的患者体内的微量元素代谢情况。生长激素缺乏患者注射hGH后，血浆和尿液中的锌平均浓度降低；而肢端肥大症患者在腺瘤切除术后，血浆中的锌含量增加，红细胞中的锌含量保持不变，尿液中的锌含量降低。在肢端肥大症患者中，血浆锌与血清hGH水平呈负相关，尿锌排泄与血清hGH水平呈正相关。在生长激素缺乏症中，治疗后血浆和红细胞中的铜含量保持不变，尿液中的铜含量升高；然而，在肢端肥大症中，手术后血浆中的铜含量增加，红细胞和尿液中的铜含量保持不变。生长激素缺乏症或肢端肥大症患者治疗后红细胞锰的平均浓度没有显著变化，但生长激素缺乏症患者治疗前红细胞锰的水平低于对照组。生长激素缺乏症患者治疗后血浆硒浓度降低，肢端肥大症患者治疗后血浆硒浓度升高。这些结果表明，hGH影响锌、铜、锰和硒的代谢。
