Salz-Steiner D, Eldor A, Vangrover D, Okon E, Ben-Chetrit E, Rachmilewitz E A, Polliack A
Am J Clin Pathol. 1984 Jul;82(1):119-23. doi: 10.1093/ajcp/82.1.119.
Two young adults with characteristic features of histiocytic medullary reticulosis (HMR) are described. Of particular interest was the development of striking clinical and laboratory features of disseminated intravascular coagulation (DIC), in the absence of sepsis in both cases. Both patients had a marked and fatal bleeding tendency. The association between neoplasia and DIC is well established, but, to the best of our knowledge, DIC presenting a major feature of HMR has not yet been described. The possible pathogenesis of DIC in HMR is discussed.
本文描述了两名具有组织细胞性髓性网状细胞增生症（HMR）特征的年轻成年人。特别值得关注的是，在这两例患者均无败血症的情况下，出现了弥散性血管内凝血（DIC）显著的临床和实验室特征。两名患者均有明显且致命的出血倾向。肿瘤与DIC之间的关联已得到充分证实，但据我们所知，以DIC为HMR主要特征的情况尚未见报道。本文讨论了HMR中DIC可能的发病机制。
