Mann J M
Am J Public Health. 1984 Jul;74(7):720-2. doi: 10.2105/ajph.74.7.720.
The rational use of rabies biologics is a difficult challenge. Pre-exposure rabies prophylaxis (PRE-RP) is one important rabies prevention strategy currently recommended by the US Public Health Service for groups considered at high risk of exposure to rabies. However, standard post-exposure rabies prophylaxis (POST-RP) appears equally effective in preventing rabies; PRE-RP still requires a limited vaccination series if a rabies exposure occurs and, at current costs, standard POST-RP may be a less expensive strategy than PRE-RP. For PRE-RP, as with other human rabies prevention strategies, the central problem is to obtain reasonable estimates of actual rabies exposure risks, which provide the rationale for well-designed programs.
合理使用狂犬病生物制品是一项艰巨的挑战。暴露前狂犬病预防（PRE-RP）是美国公共卫生服务部目前推荐给被认为有高狂犬病暴露风险人群的一项重要狂犬病预防策略。然而，标准的暴露后狂犬病预防（POST-RP）在预防狂犬病方面似乎同样有效；如果发生狂犬病暴露，PRE-RP仍需要有限的疫苗接种系列，并且以目前的成本计算，标准的POST-RP可能是比PRE-RP更便宜的策略。对于PRE-RP，与其他人类狂犬病预防策略一样，核心问题是获得对实际狂犬病暴露风险的合理估计，这为精心设计的方案提供了依据。
