硝酸甲基阿托品抑制大鼠假饲。
Atropine methyl nitrate inhibits sham feeding in the rat.
作者信息
Lorenz D, Nardi P, Smith G P
出版信息
Pharmacol Biochem Behav. 1978 Apr;8(4):405-7. doi: 10.1016/0091-3057(78)90077-1.
PMID:674252
Abstract
Atropine methyl nitrate inhibited sham feeding of a liquid diet in a dose-related manner. Identical doses of atropine methyl nitrate had no effect on sham drinking of water. This differential effect is evidence that the inhibition of sham feeding was not due to peripheral anticholinergic disruption of licking, salivating or swallowing. The results suggest that peripheral blockade of cholinergic receptors of the muscarinic type is a mechanism for eliciting satiety for food in the rat.
摘要
硝酸甲基阿托品以剂量相关的方式抑制了液体食物的假饲。相同剂量的硝酸甲基阿托品对假饮水没有影响。这种差异效应证明假饲的抑制并非由于外周抗胆碱能对舔舐、流涎或吞咽的破坏。结果表明，外周阻断毒蕈碱型胆碱能受体是引发大鼠食物饱腹感的一种机制。
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