Heyman A, Wilkinson W E, Stafford J A, Helms M J, Sigmon A H, Weinberg T
Ann Neurol. 1984 Apr;15(4):335-41. doi: 10.1002/ana.410150406.
A case-control study was performed to determine the possible roles of various environmental factors, prior illnesses, drug use, and personal habits in the development of Alzheimer's disease. Such information was collected from 40 patients with onset of dementia prior to age 70 and from 80 community control subjects matched for age, sex, and race. No significant differences were found between patients and control subjects in toxic environmental exposures, animal contacts, smoking, drinking, or unusual dietary habits. A significantly higher frequency of prior thyroid disease was found in women patients than in women control subjects (25.0% and 7.1%, respectively). A history of severe head injury was also obtained significantly more often among the patients than among the controls (15.0% and 3.8%, respectively). Aside from these differences, which may prove to be important associative factors in this illness, there appeared to be no major premorbid demographic or clinical factors associated with this form of dementia. There was evidence, however, of a genetic factor that was manifested in an excess of dementia and mental retardation (including Down's syndrome) in families of patients with Alzheimer's disease.
进行了一项病例对照研究，以确定各种环境因素、既往疾病、药物使用和个人习惯在阿尔茨海默病发病中的可能作用。这些信息来自40名70岁之前出现痴呆症状的患者以及80名年龄、性别和种族相匹配的社区对照者。在有毒环境暴露、动物接触、吸烟、饮酒或特殊饮食习惯方面，患者与对照者之间未发现显著差异。女性患者中既往甲状腺疾病的发生率显著高于女性对照者（分别为25.0%和7.1%）。患者中严重头部受伤史的比例也显著高于对照者（分别为15.0%和3.8%）。除了这些可能被证明是该疾病重要关联因素的差异外，似乎没有与这种形式的痴呆相关的主要病前人口统计学或临床因素。然而，有证据表明存在遗传因素，这在阿尔茨海默病患者的家族中表现为痴呆和智力迟钝（包括唐氏综合征）过多。
