Heckmatt J Z, Moosa A, Hutson C, Maunder-Sewry C A, Dubowitz V
Arch Dis Child. 1984 Jun;59(6):528-32. doi: 10.1136/adc.59.6.528.
The technique of needle muscle biopsy using the Bergstr öm needle has been in routine use in our muscle clinic since 1978. In an initial feasibility study 24 children had a needle and an open biopsy performed simultaneously through extension of the same incision and 22 had identical interpretation of the needle and open biopsies. Needle biopsies have subsequently been performed in 674 children and have been satisfactory for diagnostic assessment in 656. The samples have been of adequate size and comparable in quality to our previous open biopsies, with good preservation and orientation. Needle muscle biopsy under local anaesthetic is quicker and less traumatic than open biopsy and leaves only a very small scar. Sufficient muscle can be obtained for routine histological, histochemical, and electronmicroscopic diagnosis, as well as for specialised biochemical and research purposes. There seems little justification for the continued use of open biopsy for routine investigation of neuromuscular disease.
自1978年以来，我们肌肉诊所一直常规使用Bergström针进行肌肉穿刺活检技术。在一项初步可行性研究中，24名儿童通过扩大同一个切口同时进行了穿刺活检和开放性活检，其中22名儿童的穿刺活检和开放性活检结果一致。随后，对674名儿童进行了穿刺活检，其中656例的诊断评估结果令人满意。样本大小合适，质量与我们之前的开放性活检相当，保存良好且定位准确。局部麻醉下的肌肉穿刺活检比开放性活检更快，创伤更小，仅留下非常小的疤痕。可以获取足够的肌肉用于常规组织学、组织化学和电子显微镜诊断，以及专门的生化和研究目的。对于继续使用开放性活检进行神经肌肉疾病的常规检查，似乎没有什么正当理由。
