Ramani V, Torres F, Loewenson R
Arch Neurol. 1984 Jul;41(7):752-5. doi: 10.1001/archneur.1984.04050180074021.
Pattern visual evoked response (PVER) and critical frequency of photic driving (CFPD) to repetitive flash stimuli were studied in 68 consecutive patients suspected of multiple sclerosis (MS) and 15 normal controls to assess the diagnostic value of combined PVER-CFPD testing. Clinically, 38 qualified for the diagnosis of MS while 30 did not. The CFPD was found to be unreliable for detecting optic nerve dysfunction (OND) in MS, since well-defined photic driving at all frequencies above 40 flashes per second was not present in 14 patients without MS (47%) and in three normal control subjects (20%). The PVER, on the other hand, was highly sensitive and specific for OND, being abnormal in 12 patients with definite MS (92%) but in none of the normal controls. It is concluded that PVER by itself is a valuable test for the diagnosis of OND in MS and additional CFPD testing is uninformative and may even be misleading.
对68例疑似多发性硬化症（MS）的连续患者和15名正常对照者进行了模式视觉诱发电位（PVER）和对重复闪光刺激的光驱动临界频率（CFPD）研究，以评估联合PVER-CFPD检测的诊断价值。临床上，38例符合MS诊断标准，30例不符合。发现CFPD对于检测MS中的视神经功能障碍（OND）不可靠，因为在14例无MS的患者（47%）和3名正常对照者（20%）中，在每秒40次闪光以上的所有频率下均未出现明确的光驱动。另一方面，PVER对OND具有高度敏感性和特异性，12例确诊MS的患者中有异常（92%），但正常对照者均无异常。结论是，PVER本身是诊断MS中OND的有价值测试，额外的CFPD检测无信息价值，甚至可能产生误导。
