铜负荷动物肝脏微粒体部分中铜金属硫蛋白出现情况的种属差异。
Species differences in the occurrence of copper-metallothionein in the particulate fractions of the liver of copper-loaded animals.
作者信息
Mehra R K, Bremner I
出版信息
Biochem J. 1984 Apr 15;219(2):539-46. doi: 10.1042/bj2190539.
Abstract
Large amounts of Cu-metallothionein were obtained by 2-mercaptoethanol and sodium dodecyl sulphate extractions of the particulate fractions of the liver of pigs given high-Cu2+ diets or rats injected with Cu2+. Three isoproteins were purified from pig liver and characterized on the basis of their physicochemical properties, metal content and amino acid composition. No such pool of Cu-metallothionein was present in the liver of Cu2+-loaded sheep or of rats given Cu2+-supplemented diets.
摘要
通过用2-巯基乙醇和十二烷基硫酸钠对食用高铜离子日粮的猪肝脏或注射铜离子的大鼠肝脏的颗粒部分进行提取，获得了大量的铜-金属硫蛋白。从猪肝中纯化出三种同功蛋白，并根据它们的物理化学性质、金属含量和氨基酸组成进行了表征。在铜负荷的绵羊肝脏或补充铜离子日粮的大鼠肝脏中不存在这样的铜-金属硫蛋白库。
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Species differences in the occurrence of copper-metallothionein in the particulate fractions of the liver of copper-loaded animals.铜负荷动物肝脏微粒体部分中铜金属硫蛋白出现情况的种属差异。
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