给大鼠补充膳食铜对肝脏中金属硫蛋白-I的产生及其分泌到血液、胆汁和尿液中的影响。
Effects of dietary copper supplementation of rats on the occurrence of metallothionein-I in liver and its secretion into blood, bile and urine.
作者信息
Bremner I, Mehra R K, Morrison J N, Wood A M
出版信息
Biochem J. 1986 May 1;235(3):735-9. doi: 10.1042/bj2350735.
Abstract
The appearance and excretion of metallothionein-I (MT-I) was studied in rats given a diet containing 1000 mg of Cu/kg for several weeks. No significant increase in MT-I concentrations in liver, plasma or bile was detected in rats with liver copper concentrations less than 600 micrograms of Cu/g fresh wt. Above this concentration, liver MT-I concentrations increased in proportion to the increase in hepatic copper content. Plasma and bile MT-I concentrations were directly related to those in the liver and were about 10 times those in normal rats. Urinary MT-I concentration also increased 10-fold within 1 week. Fractionation of bile and urine on Sephadex G-50 revealed the presence of monomeric MT-I and a range of possible degradation products of the isoprotein.
摘要
研究了给大鼠喂食含1000毫克铜/千克的饲料数周后金属硫蛋白-I（MT-I）的出现和排泄情况。肝脏铜浓度低于600微克铜/克鲜重的大鼠，其肝脏、血浆或胆汁中的MT-I浓度未检测到显著增加。高于此浓度时，肝脏MT-I浓度随肝脏铜含量的增加而成比例增加。血浆和胆汁中的MT-I浓度与肝脏中的浓度直接相关，约为正常大鼠的10倍。尿MT-I浓度在1周内也增加了10倍。用葡聚糖凝胶G-50对胆汁和尿液进行分级分离，发现存在单体MT-I和一系列该同工蛋白可能的降解产物。
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本文引用的文献
1
A radioimmunoassay for human metallothionein.一种针对人金属硫蛋白的放射免疫测定法。
Toxicol Appl Pharmacol. 1980 Aug;55(1):94-102. doi: 10.1016/0041-008x(80)90224-0.
2
On the proposed role of metallothionein in the transport of cadmium.关于金属硫蛋白在镉运输中的假定作用。
Environ Res. 1980 Apr;21(2):360-5. doi: 10.1016/0013-9351(80)90038-9.
3
Copper- and zinc-binding proteins in sheep liver and intestine: effects of dietary levels of the metals.绵羊肝脏和肠道中铜结合蛋白和锌结合蛋白：金属膳食水平的影响。
J Nutr. 1980 Mar;110(3):460-8. doi: 10.1093/jn/110.3.460.
4
Isolation of copper thionein from rat liver.从大鼠肝脏中分离铜硫蛋白。
Arch Biochem Biophys. 1981 Apr 15;208(1):160-6. doi: 10.1016/0003-9861(81)90135-1.
5
Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.重金属对小鼠金属硫蛋白-I基因的转录调控
J Biol Chem. 1981 Jun 10;256(11):5712-6.
6
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Methods Enzymol. 1982;84:121-38. doi: 10.1016/0076-6879(82)84011-1.
7
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