Subbiah M T, Yunker R L
Biochem Biophys Res Commun. 1984 Jun 29;121(3):743-8. doi: 10.1016/0006-291x(84)90741-1.
Experimental diabetes in the rat has been shown to result in marked increases in bile acid pool and synthesis. In this study, mechanisms responsible for the increased bile acid synthesis was examined in rats made diabetic with streptozotocin. Our results indicate that a) in diabetic rats, hepatic cholesterol-7 alpha-hydroxylase activity is increased by 100%, b) this increased activity is not due to a higher stimulating activity of cell supernatant factors, but c) may be due to a non-lipoprotein factor(s) in diabetic serum capable of stimulating (by 100%) cholesterol-7 alpha-hydroxylase activity in control livers to the level noted in diabetic animals.
实验表明，大鼠患实验性糖尿病后胆汁酸池和合成量会显著增加。在本研究中，我们对用链脲佐菌素诱导糖尿病的大鼠中胆汁酸合成增加的机制进行了研究。我们的结果表明：a）糖尿病大鼠肝脏中胆固醇7α-羟化酶活性增加了100%；b）这种活性增加并非由于细胞上清因子的刺激活性增强；c）可能是由于糖尿病血清中的一种非脂蛋白因子，它能够将对照肝脏中胆固醇7α-羟化酶的活性（提高100%）刺激至糖尿病动物体内所观察到的水平。
