Widelitz M M, Gugger A M, Lakritz L
Biochem Biophys Res Commun. 1984 Jul 18;122(1):143-50. doi: 10.1016/0006-291x(84)90451-0.
Amino acids in rat brain were assayed after IP injection d-amphetamine or beta-phenylethylamine (PEA). Results revealed elevated values when one utilized 2.0-12 mg/kg of d-amphetamine. At 15 mg/kg, however, all amino acids fell into the control range except tryptophan which was elevated nearly threefold, and methionine which showed a tenfold decrease. When utilizing PEA to induce the behavioral changes only methionine is decreased at all concentrations of PEA. Chlorpromazine did not disturb the amino acid distribution induced by amphetamine or PEA. When haloperidol was utilized as the neuroleptic to prevent behavioral change there was a significant increase above control of all the amino acids including homocysteine. The implications of this are discussed in the text.
在大鼠腹腔注射d-苯丙胺或β-苯乙胺（PEA）后，对其大脑中的氨基酸进行了测定。结果显示，当使用2.0 - 12毫克/千克的d-苯丙胺时，氨基酸值升高。然而，在15毫克/千克时，除色氨酸升高近三倍和蛋氨酸下降十倍外，所有氨基酸均降至对照范围。当使用PEA诱导行为变化时，在所有PEA浓度下只有蛋氨酸减少。氯丙嗪不会干扰由苯丙胺或PEA诱导的氨基酸分布。当使用氟哌啶醇作为抗精神病药物来预防行为变化时，包括同型半胱氨酸在内的所有氨基酸均显著高于对照水平。本文将讨论其意义。
