透明质酸信号转导的调控作为人类疾病的治疗靶点。
Modulation of hyaluronan signaling as a therapeutic target in human disease.
机构信息
Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.
出版信息
Pharmacol Ther. 2022 Apr;232:107993. doi: 10.1016/j.pharmthera.2021.107993. Epub 2021 Sep 26.
Abstract
The extracellular matrix is an active participant, modulator and mediator of the cell, tissue, organ and organismal response to injury. Recent research has highlighted the role of hyaluronan, an abundant glycosaminoglycan constituent of the extracellular matrix, in many fundamental biological processes underpinning homeostasis and disease development. From this basis, emerging studies have demonstrated the therapeutic potential of strategies which target hyaluronan synthesis, biology and signaling, with significant promise as therapeutics for a variety of inflammatory and immune diseases. This review summarizes the state of the art in this field and discusses challenges and opportunities in what could emerge as a new class of therapeutic agents, that we term "matrix biologics".
摘要
细胞外基质是细胞、组织、器官和机体对损伤反应的积极参与者、调节剂和介质。最近的研究强调了透明质酸的作用，透明质酸是细胞外基质中丰富的糖胺聚糖成分，在维持体内平衡和疾病发展的许多基本生物学过程中发挥作用。在此基础上，新兴的研究表明，靶向透明质酸合成、生物学和信号转导的策略具有治疗多种炎症和自身免疫性疾病的巨大潜力。本综述总结了该领域的最新进展，并讨论了这一领域可能成为一类新型治疗药物（我们称之为“基质生物制剂”）所面临的挑战和机遇。
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