Mantero F, Procidano M, Vicariotto M A, Girolami A
Br J Clin Pharmacol. 1984;17 Suppl 1(Suppl 1):94S-96S. doi: 10.1111/j.1365-2125.1984.tb02438.x.
In patients receiving long-term acenocoumarin treatment, the effect on anticoagulant activity of atenolol (100 mg once-daily) and metoprolol (100 mg twice daily) was compared in a randomised within-patient open trial. No significant differences were demonstrated between mean prothrombin time and Thrombotest during treatment with atenolol, metoprolol or placebo. These data do not suggest the existence of an interaction between acenocoumarin and the moderately lipophilic beta-adrenoceptor blocker metoprolol, or the hydrophilic beta-adrenoceptor blocker atenolol. The results are discussed in the light of published data for the highly lipophilic beta-adrenoceptor blocker propranolol.
在接受长期醋硝香豆素治疗的患者中，通过一项随机的患者自身开放试验，比较了阿替洛尔（每日一次，100毫克）和美托洛尔（每日两次，100毫克）对抗凝活性的影响。在使用阿替洛尔、美托洛尔或安慰剂治疗期间，凝血酶原时间均值和血栓试验之间未显示出显著差异。这些数据并不表明醋硝香豆素与中度亲脂性β-肾上腺素能受体阻滞剂美托洛尔或亲水性β-肾上腺素能受体阻滞剂阿替洛尔之间存在相互作用。根据已发表的关于高度亲脂性β-肾上腺素能受体阻滞剂普萘洛尔的数据对结果进行了讨论。
