Harry J D, Cruickshank J M, Young J, Barker N
Eur J Clin Pharmacol. 1981;20(1):9-15. doi: 10.1007/BF00554660.
The effects or oral atenolol (100 mg once/day) and metoprolol (100 mg once/day, 100 mg twice/day and 300 mg once/day) have been compared with placebo on the heart rate and systolic blood pressure responses to exercise in 5 healthy volunteers. The drugs were given for 5 days in a double blind randomised fashion with each volunteer receiving each dose of drug. Measurements were made after the first dose on day 1 and after 5 days of dosing. The results on both heart rate and systolic blood pressure showed that overall (over a 24 h period) after acute (day 1) or after chronic (5 days) dosing, atenolol 100 mg once/day, metoprolol 100 mg twice/day and 300 mg once/day, were equivalent as beta-adrenoceptor blocking doses. Thus milligram for milligram atenolol and metoprolol do not produce equivalent blockade on the cardiovascular system of man.
在5名健康志愿者中，比较了口服阿替洛尔（每日1次，每次100毫克）和美托洛尔（每日1次，每次100毫克；每日2次，每次100毫克；每日1次，每次300毫克）与安慰剂对运动时心率和收缩压反应的影响。药物以双盲随机方式给药5天，每名志愿者接受每种剂量的药物。在第1天首次给药后和给药5天后进行测量。心率和收缩压的结果均显示，总体而言（在24小时期间），急性（第1天）或慢性（5天）给药后，每日1次，每次100毫克的阿替洛尔、每日2次，每次100毫克和美托洛尔每日1次，每次300毫克，作为β肾上腺素能受体阻滞剂剂量是等效的。因此，每毫克阿替洛尔和美托洛尔对人体心血管系统的阻滞作用并不等效。
