氟米龙（FML）对皮质类固醇反应者眼压的影响。
Effect of fluorometholone (FML) on the intraocular pressure of corticosteroid responders.
作者信息
Morrison E, Archer D B
出版信息
Br J Ophthalmol. 1984 Aug;68(8):581-4. doi: 10.1136/bjo.68.8.581.
Abstract
Steroid responsiveness to dexamethasone was determined in a large family with an established dominant form of chronic simple glaucoma. The high and intermediate steroid responders were then tested with fluorometholone--a steroid which is claimed to have a reduced risk of increasing intraocular pressure. It was found that fluorometholone had a much less pronounced ocular hypertensive effect than dexamethasone. However, one patient showed a comparable response on both drugs, and this suggests that some caution must still be exercised when using the drug on susceptible individuals. Fluorometholone was also found to be more irritable to the eye than dexamethasone.
摘要
在一个患有显性遗传型慢性单纯性青光眼的大家族中，测定了地塞米松的类固醇反应性。然后，对高反应者和中度反应者使用氟米龙进行测试，氟米龙是一种据称可降低眼压升高风险的类固醇。结果发现，氟米龙的眼压升高作用比地塞米松要小得多。然而，有一名患者对这两种药物的反应相当，这表明在对易感个体使用该药物时仍需谨慎。还发现氟米龙比地塞米松对眼睛的刺激性更大。
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