0.1%氟米龙与0.1%地塞米松对眼压影响的对比研究。
Comparative study of the intraocular pressure effects of fluorometholone 0.1% versus dexamethasone 0.1%.
作者信息
Akingbehin A O
出版信息
Br J Ophthalmol. 1983 Oct;67(10):661-3. doi: 10.1136/bjo.67.10.661.
Abstract
The intraocular pressure effect of fluorometholone 0.1% was compared with that of dexamethasone 0.1% by performing corticosteroid provocative tests on 24 matched pairs of eyes. Fifteen of the 24 dexamethasone treated eyes, 62.5%, showed a change in intraocular pressure greater than 5 mmHg, with mean delta P = 8.58 mmHg and range 0 to +20 mmHg. Only 2 of the 24 fluorometholone treated eyes, 8.3%, showed a change in pressure greater than 5 mmHg, with mean delta P = 2.96 mmHg and range -2 to +14 mmHg. There was a highly statistically significant difference between the intraocular pressure effects of topical dexamethasone and fluorometholone (correlated t test, p less than 0.001). Fluorometholone would appear to be the topical steroid of choice for patients with glaucoma and other known steroid responders when topical steroid treatment is indicated.
摘要
通过对24对匹配的眼睛进行皮质类固醇激发试验，比较了0.1%氟米龙与0.1%地塞米松的眼压效应。在接受地塞米松治疗的24只眼中，有15只（62.5%）眼压变化大于5 mmHg，平均眼压变化值（ΔP）为8.58 mmHg，范围为0至+20 mmHg。在接受氟米龙治疗的24只眼中，只有2只（8.3%）眼压变化大于5 mmHg，平均ΔP为2.96 mmHg，范围为-2至+14 mmHg。局部应用地塞米松和氟米龙的眼压效应之间存在高度统计学显著差异（相关t检验，p<0.001）。当需要局部应用类固醇治疗时，对于青光眼患者和其他已知的类固醇反应者，氟米龙似乎是首选的局部类固醇药物。
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