Non-haemolytic febrile transfusion reactions (NHFTR) are commonly associated with the production of leucocyte antibodies, especially in multitransfused patients. These reactions can be prevented or ameliorated by the transfusion of leucocyte depleted red cells. Manual centrifugation techniques are least effective and risk the loss of excessive red cells. Saline washing can be effective, but is either tedious (manual techniques) or results in slight excess red cell losses (machine techniques). Sedimentation with high molecular weight polymers such as dextran produce excellent leucocyte depletion and small red cell losses. Filtration is both relatively straightforward and relatively cheap, and results in very effective red cell depletion with acceptable red cell losses. Microaggregate filtration is an alternative low cost bedside technique whose effectiveness does not depend entirely on maximum total leucocyte depletion. Freezing and thawing of red cells is very effective but is costly. Whatever technique is chosen, leucocyte depletion of at least 80% should be aimed for. The final choice however will depend on factors such as available facilities, experience and expense, and additional clinical factors such as the requirements for platelet depletion and plasma removal.
非溶血性发热性输血反应（NHFTR）通常与白细胞抗体的产生有关，尤其是在多次输血的患者中。通过输注去除白细胞的红细胞可以预防或减轻这些反应。手工离心技术效果最差，且有损失过多红细胞的风险。盐水洗涤可能有效，但要么很繁琐（手工技术），要么会导致轻微过量的红细胞损失（机器技术）。用高分子量聚合物如右旋糖酐进行沉降可实现出色的白细胞去除效果，且红细胞损失较小。过滤相对简单且成本较低，能有效去除白细胞，同时红细胞损失在可接受范围内。微聚体过滤是一种替代的低成本床边技术，其有效性并不完全取决于最大程度的总白细胞去除。红细胞的冷冻和融化非常有效，但成本高昂。无论选择何种技术，白细胞去除率应至少达到80%。然而，最终的选择将取决于可用设备、经验和费用等因素，以及血小板去除和血浆去除要求等其他临床因素。
