Ching M
Can J Physiol Pharmacol. 1984 Jun;62(6):654-7. doi: 10.1139/y84-107.
Physiological responses to anesthetic doses of four chemically dissimilar agents, namely, Althesin, urethane, chloralose-urethane, and pentobarbital sodium were compared in rats. The tail-flick test revealed Althesin had greater antinociceptive potency than urethane, chloralose-urethane, and pentobarbital, but its duration of action was shorter than that of chloralose-urethane. Althesin produced minimal or no suppression of core body temperature and mean arterial pressure, and only moderate reduction of mean pulse pressure. The heart rate and respiratory rate of Althesin-treated rats were slower than those of chloralose-urethane and urethane-treated counterparts, respectively, but were not significantly decreased from normal controls. It is concluded that Althesin is a suitable anesthetic for short-term surgery and for studies of body temperature, heart rate, and mean arterial pressure. Because release of gonadotropin-releasing hormone into hypophysial portal blood can be observed under Althesin but is suppressed or blocked by chloralose-urethane, urethane, and pentobarbital, Althesin is the anesthetic of choice in studies concerned with the neural control of ovulatory hormone release.
在大鼠中比较了四种化学性质不同的麻醉剂量药物，即阿法沙龙、乌拉坦、氯醛糖-乌拉坦和戊巴比妥钠的生理反应。甩尾试验显示，阿法沙龙的镇痛效力比乌拉坦、氯醛糖-乌拉坦和戊巴比妥更强，但其作用持续时间比氯醛糖-乌拉坦短。阿法沙龙对核心体温和平均动脉压的抑制作用最小或无抑制作用，仅使平均脉压适度降低。阿法沙龙处理组大鼠的心率和呼吸频率分别比氯醛糖-乌拉坦和乌拉坦处理组的大鼠慢，但与正常对照组相比无显著降低。结论是，阿法沙龙是短期手术以及体温、心率和平均动脉压研究的合适麻醉剂。由于在阿法沙龙麻醉下可观察到促性腺激素释放激素释放到垂体门脉血中，但在氯醛糖-乌拉坦、乌拉坦和戊巴比妥麻醉下受到抑制或阻断，因此在涉及排卵激素释放神经控制的研究中，阿法沙龙是首选麻醉剂。
