Bousquet P, Gaertner M, Feldman J, Bloch R
C R Seances Soc Biol Fil. 1977;171(5):1129-33.
The central hypotensive agent, clonidine (30 microgram/kg i.v.) has been injected in normotensive rats anesthetized with various agents. This dose of clonidine elicits usually a biphasic blood pressure response, i.e. a transient increase due to peripheral vasoconstriction, followed by a long lasting decrease. This has been observed in the animals anesthetized with pentobarbitone as well as with urethane. The hypotensive effect is abolished during chloralose, ketamine or Alfatésine anesthesia. These data emphasize that some anesthetics mays particularly modify the effects of centrally acting cardiovascular drugs.
已将中枢性降压药可乐定（静脉注射30微克/千克）注射到用各种药剂麻醉的正常血压大鼠体内。该剂量的可乐定通常会引起双相血压反应，即由于外周血管收缩导致的短暂升高，随后是持久下降。在用戊巴比妥和氨基甲酸乙酯麻醉的动物中均观察到这种情况。在氯醛糖、氯胺酮或阿法西丁麻醉期间，降压作用消失。这些数据强调，某些麻醉剂可能会特别改变中枢作用的心血管药物的效果。
