Yamashita K, Hayashi H, Mure K, Ishikawa M, Shimizu T
Cancer. 1986 Jan 1;57(1):69-74. doi: 10.1002/1097-0142(19860101)57:1<69::aid-cncr2820570115>3.0.co;2-p.
The presence of serum immunosuppressive substance (IS) was determined in 134 patients with malignant gynecologic tumors (105 cervical cancers, 15 endometrial cancers, and 14 ovarian cancers), 45 patients with benign gynecologic tumors (33 uterine myomas and 12 ovarian tumors), 10 patients with severe inflammatory diseases, 326 pregnant women, and 48 healthy controls. The mean levels and percentages of positive levels (greater than 750 micrograms/ml) in both the groups of cancer patients and the group of patients with severe inflammatory diseases were significantly higher than those in the groups of patients with benign tumors or the control group. In pregnant women, however, the majority of serum levels were within a normal range, showing relatively elevated levels in the first trimester. In the patients with malignancies (cervical, endometrial, and ovarian cancers), extremely elevated levels (greater than 1000 micrograms/ml) suggested an active or a progressive state of the malignancies. It became clear that serial IS determinations are valuable for monitoring the disease state or judging the effect of therapy.
对134例妇科恶性肿瘤患者（105例宫颈癌、15例子宫内膜癌和14例卵巢癌）、45例妇科良性肿瘤患者（33例子宫肌瘤和12例卵巢肿瘤）、10例重症炎症性疾病患者、326例孕妇及48例健康对照者测定了血清免疫抑制物质（IS）。癌症患者组和重症炎症性疾病患者组的平均水平及阳性水平百分比（大于750微克/毫升）均显著高于良性肿瘤患者组或对照组。然而，孕妇的大多数血清水平在正常范围内，在孕早期呈现相对升高的水平。在恶性肿瘤患者（宫颈癌、子宫内膜癌和卵巢癌）中，极高水平（大于1000微克/毫升）提示恶性肿瘤处于活跃或进展状态。很明显，连续测定IS对于监测疾病状态或判断治疗效果具有重要价值。
