Anderström C, Hansson H A, Johansson S L
Cancer. 1984 Sep 1;54(5):876-81. doi: 10.1002/1097-0142(19840901)54:5<876::aid-cncr2820540520>3.0.co;2-f.
Scanning electron microscopy (SEM) was performed on specimens from 16 patients with low-grade tumors, and 4 patients with benign lesions of the upper urinary tract. Pleomorphic microvilli could be seen at a low frequency on the majority of the tumor specimens as well as on surface cells of specimens from patients with inverted papilloma, fibroepithelial polyp, and hydronephrosis. The SEM appearance of the lining cells was similar whether the specimen was obtained from a patient with a tumor, or an inflammatory or proliferative lesion. Furthermore, pleomorphic microvilli were observed in five histologically normal bladders in which the covering cells had been rubbed off with a cold loop of a resectoscope. Pleomorphic microvilli are thus not morphologic markers of preneoplastic hyperplasia or tumor. It is likely that their presence merely reflects an increased rate of detachment of superficial epithelial cells which are replaced by cells from the deeper part of the epithelium. The demonstration of pleomorphic microvilli is therefore of questionable value in the preoperative diagnosis of tumors of the upper urinary tract and, consequently, their significance must be re-evaluated.
对16例低级别肿瘤患者以及4例上尿路良性病变患者的标本进行了扫描电子显微镜（SEM）检查。在大多数肿瘤标本以及内翻性乳头状瘤、纤维上皮息肉和肾积水患者标本的表面细胞上，均可低频见到多形性微绒毛。无论标本取自肿瘤患者、炎症性或增生性病变患者，衬里细胞的SEM表现均相似。此外，在5个组织学正常的膀胱中观察到多形性微绒毛，这些膀胱的覆盖细胞已被电切镜的冷环刮除。因此，多形性微绒毛并非癌前增生或肿瘤的形态学标志物。它们的存在可能仅仅反映了浅表上皮细胞脱落速率的增加，这些细胞被来自上皮更深层的细胞所取代。因此，多形性微绒毛在上尿路肿瘤术前诊断中的价值存疑，其意义必须重新评估。
