Bamberg M, Metz K, Alberti W, Heckemann R, Schulz U
Cancer. 1984 Sep 1;54(5):903-6. doi: 10.1002/1097-0142(19840901)54:5<903::aid-cncr2820540525>3.0.co;2-d.
This case report concerns an endodermal sinus tumor (EST) arising in the pineal region of a 16-year-old boy who died 3 months after radiation. He developed extensive abdominal metastases through a ventriculoperitoneal shunt, whereas the primary tumor and a suprasellar metastasis could be controlled by radiotherapy, demonstrated by autopsy. The histologic diagnosis was supported by an elevated level of alpha-fetoprotein in serum and the demonstration of this marker in the tumor tissue by immunoperoxidase method. The poor diagnosis of all previously reported cases with pineal EST requires a combined modality of surgical approach, radiotherapy, and concomitant chemotherapy.
本病例报告涉及一名16岁男孩松果体区发生的内胚窦瘤（EST），该男孩在放疗后3个月死亡。他通过脑室腹腔分流出现广泛的腹部转移，而尸检显示，原发性肿瘤和鞍上转移灶可通过放疗得到控制。血清甲胎蛋白水平升高以及通过免疫过氧化物酶法在肿瘤组织中证实该标志物支持了组织学诊断。所有先前报道的松果体EST病例诊断不佳，需要手术、放疗和同步化疗相结合的治疗方式。
