Hietanen M, Teräväinen H
Department of Neurology, University of Helsinki, Finland.
J Neurol Neurosurg Psychiatry. 1988 Feb;51(2):244-9. doi: 10.1136/jnnp.51.2.244.
One hundred and eight noninstitutionalized patients with Parkinson's disease were studied to find out whether the age of disease onset affects patients' cognitive, memory and psychomotor performance. "Early onset" patients (whose disease began before 60 years of age) showed a wide spectrum of impairments in neuropsychological performance compared with age-matched normal subjects. However, only one (2%) of these patients was demented according to DSM III criteria. Dementia was more frequent in patients with equivalent disease duration, but with late onset of disease (over 60 years); 13 of such patients (25%) were demented. The present study supports previous findings which show that dementia increases with advancing age in Parkinson's disease. It also suggests that cognitive changes are also found in patients with early onset of disease.
对108名非机构化帕金森病患者进行了研究，以确定发病年龄是否会影响患者的认知、记忆和精神运动表现。“早发型”患者（疾病在60岁之前开始）与年龄匹配的正常受试者相比，在神经心理学表现上存在广泛的损伤。然而，根据《精神疾病诊断与统计手册》第三版标准，这些患者中只有1名（2%）患有痴呆症。在疾病持续时间相同但发病较晚（60岁以上）的患者中，痴呆症更为常见；这类患者中有13名（25%）患有痴呆症。本研究支持先前的研究结果，即帕金森病患者的痴呆症会随着年龄的增长而增加。它还表明，在疾病早发的患者中也发现了认知变化。
