Nelson R L
Dis Colon Rectum. 1984 Jul;27(7):459-61. doi: 10.1007/BF02555539.
An hypothesis is presented to explain the changing pattern of colorectal cancer seen within the United States and other western countries in the last 30 years, the simultaneous increase of right-sided colonic cancer and disappearance of rectal cancer. Review of experimental and epidemiologic data suggests that this change may be due to a new systemic deficiency of the trace element, selenium. This deficiency has arisen not just from decreased consumption of selenium in the last 30 years, but also from increased consumption of zinc and fluoride, which may antagonize the effect of selenium.
本文提出了一种假说，用以解释过去30年在美国及其他西方国家所观察到的结直肠癌变化模式，即右侧结肠癌发病率的同时上升以及直肠癌的消失。对实验和流行病学数据的回顾表明，这种变化可能是由于微量元素硒出现了新的全身性缺乏。这种缺乏不仅是因为过去30年硒摄入量减少，还因为锌和氟摄入量增加，它们可能会拮抗硒的作用。
