Loker E S, Yui M A, Bayne C J
Exp Parasitol. 1984 Aug;58(1):56-62. doi: 10.1016/0014-4894(84)90020-1.
The resistance or susceptibility of Biomphalaria glabrata strains to strains of Schistosoma mansoni, the human blood fluke, are evidenced by the responses of snail hemocytes to sporocysts of the schistosome, both in vivo and in vitro. It is now reported that living sporocysts of the PR1 strain of S. mansoni agglutinate in the plasma of all tested strains of B. glabrata, in contrast to fixed sporocysts which agglutinate only in plasma from resistant snail strains. The agglutinating activity in resistant plasmas is not divalent cation dependent, and was not inhibited by the 26 carbohydrates and four amino acids tested. In addition, the observation that gelatinous deposits develop on transforming miracidia-sporocysts in B. glabrata plasmas is also reported. Both the agglutination and gel-formation phenomena may facilitate recognition of, and attacks on, sporocysts, thereby contributing to susceptibility and resistance in this host-parasite system.
光滑双脐螺菌株对人体血吸虫曼氏血吸虫菌株的抗性或易感性，通过蜗牛血细胞在体内和体外对血吸虫子孢子囊的反应得以证明。据报道，曼氏血吸虫PR1菌株的活子孢子囊在所有测试的光滑双脐螺菌株血浆中都会发生凝集，而固定的子孢子囊仅在抗性蜗牛菌株的血浆中凝集。抗性血浆中的凝集活性不依赖二价阳离子，且不受所测试的26种碳水化合物和4种氨基酸的抑制。此外，还报道了在光滑双脐螺血浆中，转化毛蚴-子孢子囊上会形成凝胶状沉积物。凝集和凝胶形成现象都可能有助于识别和攻击子孢子囊，从而在这个宿主-寄生虫系统中导致易感性和抗性。
