Meyer M E, Smith R L, Van Hartesveldt C
Dev Psychobiol. 1984 Jul;17(4):383-9. doi: 10.1002/dev.420170405.
The effects of a single subcutaneous injection of haloperidol (1 or 10 mg/kg) or the vehicle solution on three kinds of behavioral inhibition were investigated in rats of 10, 15, and 20 days of age. The behaviors measured were tonic immobility, a response induced by placing an animal on its back supported by a V-shaped trough; the dorsal immobility response, which can be elicited in young rodents by grasping the skin of the dorsal surface of the neck and lifting the animal into the air; and catalepsy, a form of immobility in which animals remain in unusual postures but are capable of righting themselves, and which can be elicited by drugs which block dopamine receptors. Haloperidol (10 mg/kg) significantly potentiated the duration of tonic immobility only at 10 days of age; potentiated catalepsy at all age levels, but significantly less in the 15-day-old rats than in the 10- or 20-day-old rats; and potentiated the duration of the dorsal immobility response in the 10- and 20-day-old animals but not in the 15-day-olds. These results are discussed with respect to the development of neurotransmitter systems in the brain.
研究了单次皮下注射氟哌啶醇（1或10毫克/千克）或溶剂对10日龄、15日龄和20日龄大鼠三种行为抑制的影响。所测量的行为包括紧张性不动，这是一种将动物仰卧在V形槽上所诱发的反应；背侧不动反应，可通过抓住幼鼠颈部背侧皮肤并将其举到空中诱发；以及僵住症，这是一种不动形式，动物保持异常姿势但能够自行翻身，可由阻断多巴胺受体的药物诱发。氟哌啶醇（10毫克/千克）仅在10日龄时显著延长紧张性不动的持续时间；在所有年龄水平上均增强僵住症，但在15日龄大鼠中增强程度明显低于10日龄或20日龄大鼠；在10日龄和20日龄动物中增强背侧不动反应的持续时间，但在15日龄动物中未增强。结合大脑中神经递质系统的发育对这些结果进行了讨论。
