Meyer M E, Cottrell G A, Van Hartesveldt C
Department of Psychology, University of Florida, Gainesville 32611.
Pharmacol Biochem Behav. 1993 Jan;44(1):157-60. doi: 10.1016/0091-3057(93)90294-4.
The effects of intracerebral microinjections of 4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4- fluorophenyl)-1-butanone (haloperidol) (1.0 microgram, 0.5 microliter) in five regions of the brain were tested on the duration of the dorsal immobility response (DIR) and the cling and bar catalepsy in the rat. The duration of the DIR was significantly potentiated (but not the cling and bar catalepsy) following 2-h postinjection of haloperidol in the caudate putamen, nucleus accumbens, and globus pallidus but not in the substantia nigra pars compacta or cortex. These data further expand the previous evidence of regional variations in dopamine to the effects upon inhibitory behaviors.
在大鼠的五个脑区进行脑内微量注射4-[4-(4-氯苯基)-4-羟基-1-哌啶基]-1-(4-氟苯基)-1-丁酮（氟哌啶醇）（1.0微克，0.5微升），测试其对背侧不动反应（DIR）持续时间以及大鼠的攀附和杆状木僵的影响。在尾状核、伏隔核和苍白球注射氟哌啶醇2小时后，DIR的持续时间显著增强（但攀附和杆状木僵未增强），而在黑质致密部或皮层注射后则无此现象。这些数据进一步扩展了先前关于多巴胺区域差异对抑制行为影响的证据。
