Rubel L R, Rabin L, Seeff L B, Licht H, Cuccherini B A
Hepatology. 1984 Jul-Aug;4(4):671-7. doi: 10.1002/hep.1840040418.
Primary biliary cirrhosis is infrequently diagnosed in men, so that the clinical, biochemical and histopathological spectrum of this disease in men has not been evaluated. Therefore, we studied 30 men who had a histological diagnosis of primary biliary cirrhosis and had positive tests for antimitochondrial antibodies. Five patients had no hepatobiliary symptoms, and two of these patients had neither biochemical nor histological evidence of cholestasis. These 30 male patients' findings were compared with the findings in 30 age-matched women who also had primary biliary cirrhosis and antimitochondrial antibodies. Six of these patients were asymptomatic. Clinical findings and symptomatic status, in addition to biochemical and histopathological features, were generally similar in both male and female patients. The possible significance of higher serum alkaline phosphatase activities and lower frequency of occurrence of piecemeal necrosis in men with primary biliary cirrhosis, as compared with women, requires further study.
原发性胆汁性肝硬化在男性中很少被诊断出来，因此这种疾病在男性中的临床、生化和组织病理学特征尚未得到评估。为此，我们研究了30名经组织学诊断为原发性胆汁性肝硬化且抗线粒体抗体检测呈阳性的男性患者。5名患者没有肝胆症状，其中2名患者既没有胆汁淤积的生化证据也没有组织学证据。将这30名男性患者的研究结果与30名年龄匹配、同样患有原发性胆汁性肝硬化且抗线粒体抗体呈阳性的女性患者的结果进行了比较。这些女性患者中有6名无症状。除生化和组织病理学特征外，男性和女性患者的临床症状和症状状态总体相似。与女性相比，原发性胆汁性肝硬化男性患者血清碱性磷酸酶活性较高且桥接坏死发生率较低的潜在意义需要进一步研究。
