Pylypiw H M, Zubroff J R, Magee P N, Harrington G W
J Cancer Res Clin Oncol. 1984;108(1):66-70. doi: 10.1007/BF00390975.
The distribution in the body, rate of disappearance from organs, tissues, and blood, and excretion in the urine of N-nitrosomethylaniline (NMA, N-nitrosophenylmethylamine) was investigated after various single doses given IP to rats. The compound was distributed fairly evenly throughout the body with no preferential concentration in the esophagus, its target organ for carcinogenicity. The high lipid solubility of NMA did not lead to any increased accumulation in adipose tissue. According to its rate of disappearance from circulating blood and tissues of rats, and from the whole bodies of mice after injection, NMA appeared to be rapidly metabolized. Methylaniline (MA), the parent amine, was found in the urine after administration of NMA but the amounts present were small relative to the dose of NMA. Administered MA was mainly excreted unchanged in the urine, suggesting that denitrosation of NMA could only be a minor metabolic pathway. No volatile nitrosamines were found in the urine or blood of rats given NMA, indicating that little, if any, transnitrosation could have occurred to yield these compounds.
给大鼠腹腔注射不同单剂量的N-亚硝基甲基苯胺（NMA，N-亚硝基苯基甲胺）后，研究了其在体内的分布、从器官、组织和血液中消失的速率以及在尿液中的排泄情况。该化合物在全身分布相当均匀，在其致癌靶器官食管中没有优先富集。NMA的高脂溶性并未导致其在脂肪组织中的蓄积增加。根据其从大鼠循环血液和组织以及注射后小鼠全身消失的速率，NMA似乎能被快速代谢。给予NMA后，在尿液中发现了母体胺甲基苯胺（MA），但其含量相对于NMA的剂量较少。给予的MA主要以原形经尿液排泄，这表明NMA的脱亚硝化作用可能只是一条次要的代谢途径。在给予NMA的大鼠尿液或血液中未发现挥发性亚硝胺，这表明即使有转亚硝化作用产生这些化合物，其发生的程度也很小。
