真核生物氨酰-tRNA合成酶复合体：关于其结构与功能的推测
The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function.
作者信息
Deutscher M P
出版信息
J Cell Biol. 1984 Aug;99(2):373-7. doi: 10.1083/jcb.99.2.373.
Abstract
Aminoacyl-tRNA synthetases from eucaryotic cells generally are isolated as high molecular weight complexes comprised of multiple synthetase activities, and often containing other components as well. A model is proposed for the synthetase complex in which hydrophobic extensions on the proteins serve to maintain them in their high molecular weight form, but are not needed for catalytic activity. The structural similarity of these enzymes to certain membrane-bound proteins, and its implications for synthetase localization and function in vivo, are discussed.
摘要
真核细胞中的氨酰-tRNA合成酶通常以高分子量复合物的形式被分离出来，这些复合物由多种合成酶活性组成，并且常常还含有其他成分。本文提出了一个关于合成酶复合物的模型，其中蛋白质上的疏水延伸部分有助于将它们维持在高分子量形式，但催化活性并不需要这些延伸部分。文中还讨论了这些酶与某些膜结合蛋白的结构相似性，以及这种相似性对合成酶在体内的定位和功能的影响。
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The eucaryotic aminoacyl-tRNA synthetase complex: suggestions for its structure and function.真核生物氨酰-tRNA合成酶复合体：关于其结构与功能的推测
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本文引用的文献
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Multienzyme complexes of eukaryotic aminoacyl-tRNA synthetases.真核生物氨酰-tRNA合成酶的多酶复合物。
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Properties of the cytoplasmic glutamyl-tRNA synthetase in high molecular weight complexes from bovine brain.来自牛脑的高分子量复合物中细胞质谷氨酰胺-tRNA合成酶的特性
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Characterization of a homogeneous arginyl- and lysyl-tRNA synthetase complex isolated from rat liver. Arginyl- and lysyl-tRNA synthetases contain carbohydrates.从大鼠肝脏中分离出的一种均一的精氨酰 - 赖氨酰 - tRNA合成酶复合物的特性。精氨酰 - 和赖氨酰 - tRNA合成酶含有碳水化合物。
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