Ueshima H, Shimamoto T, Iida M, Konishi M, Tanigaki M, Doi M, Tsujioka K, Nagano E, Tsuda C, Ozawa H
J Chronic Dis. 1984;37(7):585-92. doi: 10.1016/0021-9681(84)90008-0.
A significant positive relationship was found between alcohol intake and blood pressure for men 40-69 years old living in urban Osaka (492 men) and in rural Akita (395 men), Japan, surveyed from 1975 to 1977. Both mean blood pressure and the prevalence of hypertension were related to alcohol intake in a graded fashion. Stepwise multiple regression also showed that both systolic and diastolic pressure were associated with alcohol intake independent of ponderosity index, serum cholesterol, triglycerides, hemoglobin, uric acid, smoking, and age. This cross-sectional study indicates a continuous--and not a threshold--relationship between alcohol and blood pressure, with the effect of even moderate consumption, e.g. 28-55 g per day (equivalent to about 2-4 U.S. drinks per day).
1975年至1977年对居住在日本大阪市区（492名男性）和秋田农村地区（395名男性）年龄在40 - 69岁的男性进行调查发现，酒精摄入量与血压之间存在显著正相关。平均血压和高血压患病率均与酒精摄入量呈分级相关。逐步多元回归分析还显示，收缩压和舒张压均与酒精摄入量相关，且不受肥胖指数、血清胆固醇、甘油三酯、血红蛋白、尿酸、吸烟及年龄的影响。这项横断面研究表明，酒精与血压之间存在持续而非阈值的关系，即使适度饮酒，如每天28 - 55克（相当于每天约2 - 4杯美国标准饮品）也会产生影响。
