Hopp R J, Bewtra A K, Nair N M, Townley R G
J Allergy Clin Immunol. 1984 Aug;74(2):154-8. doi: 10.1016/0091-6749(84)90279-3.
The provocative dose of inhaled methacholine required to cause a 20% drop in the forced expiratory volume in 1 sec was evaluated in two selected pediatric populations. On the basis of a standardized respiratory questionnaire, 165 individuals 5 to 21 yr of age were identified. Included were 110 normal nonatopic individuals and 55 current asthmatic subjects. Methacholine inhalation challenges were performed by use of a standard inhalation procedure. Fifty-four (98.1%) of the asthmatic subjects responded to methacholine with a 20% drop in the forced expiratory volume in 1 sec. Seventy (63.1%) of the normal individuals did not respond to methacholine. The specificity and sensitivity of the methacholine challenge was best obtained at a provocative dose of 100 breath units of methacholine.
在两个选定的儿科人群中评估了使一秒用力呼气量下降20%所需的吸入乙酰甲胆碱激发剂量。根据一份标准化的呼吸问卷，确定了165名5至21岁的个体。其中包括110名正常非特应性个体和55名当前哮喘患者。使用标准吸入程序进行乙酰甲胆碱吸入激发试验。54名（98.1%）哮喘患者对乙酰甲胆碱有反应，一秒用力呼气量下降20%。70名（63.1%）正常个体对乙酰甲胆碱无反应。乙酰甲胆碱激发试验的特异性和敏感性在乙酰甲胆碱激发剂量为100呼吸单位时最佳。
