Rothstein T L, Vastola A P
J Immunol. 1984 Sep;133(3):1151-4.
The fine specificity of idiotype suppression induced early in ontogeny was investigated in the murine A/J anti-azophenylarsonate (Ar) response. Suppression was induced with two hapten-inhibitable, homologous monoclonal anti-idiotopic antibodies, AI and MB, that recognize partially overlapping sets of Ar-immune antibodies. Suppression was found to be idiotope-specific when adult mice were exposed to anti-idiotope as neonates; suppression was also idiotope specific when adult mice were exposed to anti-idiotope during fetal (through maternal inoculation) and neonatal life. Of particular interest, anti-idiotope, administered maternally, induced suppression in offspring first immunized with Ar as neonates, and this suppression was idiotope specific too. Thus, AI and MB induce idiotope-specific suppression in mice exposed to anti-idiotope early in ontogeny. These results parallel previous findings in adult mice and suggest that the mechanism of suppression in very young mice is the same as that in adults.
在小鼠A/J抗偶氮苯砷酸盐（Ar）反应中，研究了个体发育早期诱导的独特型抑制的精细特异性。用两种可被半抗原抑制的同源单克隆抗独特型抗体AI和MB诱导抑制，这两种抗体识别Ar免疫抗体的部分重叠集。当成年小鼠在新生期接触抗独特型时，发现抑制是独特型特异性的；当成年小鼠在胎儿期（通过母体接种）和新生期接触抗独特型时，抑制也是独特型特异性的。特别有趣的是，母体给予的抗独特型在新生期首次用Ar免疫的后代中诱导了抑制，并且这种抑制也是独特型特异性的。因此，AI和MB在个体发育早期接触抗独特型的小鼠中诱导独特型特异性抑制。这些结果与成年小鼠先前的发现相似，表明非常年幼小鼠中的抑制机制与成年小鼠相同。
