用合成肽免疫接种克服幼鼠母体抗麻疹病毒抗体免疫抑制作用的潜力。
The potential of immunization with synthetic peptides to overcome the immunosuppressive effect of maternal anti-measles virus antibodies in young mice.
作者信息
Obeid O E, Steward M W
机构信息
Department of Clinical Sciences, London School of Hygiene and Tropical Medicine, U.K.
出版信息
Immunology. 1994 May;82(1):16-21.
In this paper, we describe the results of experiments designed to test the hypothesis that immunogenic synthetic peptides representing non-immunodominant B- and T-cell epitopes of measles virus (MV) proteins can overcome the suppressive effect of maternal antibodies and induce anti-MV antibodies in young mice in the presence of maternal antibody to the virus. We have established a mouse model of immunosuppression by maternal antibody of both anti-MV and anti-peptide antibody responses in the young. Results obtained with this model immunization of young mice with a cocktail of synthetic peptides can overcome the suppression by maternal anti-MV antibodies and results in the induction of anti-peptide antibodies which recognize the virus. This work indicates that appropriately selected synthetic peptides have potential as vaccines which can be immunogenic and induce antibodies reactive with the virus-virus antibodies. in the presence of maternal anit-virus antibodies.
在本文中，我们描述了旨在检验以下假设的实验结果：代表麻疹病毒（MV）蛋白非免疫显性B细胞和T细胞表位的免疫原性合成肽能够克服母源抗体的抑制作用，并在幼鼠体内存在针对该病毒的母源抗体时诱导产生抗MV抗体。我们建立了一个幼鼠因母源抗体对MV和抗肽抗体反应产生免疫抑制的小鼠模型。用合成肽混合物对该模型中的幼鼠进行免疫接种所获得的结果表明，其能够克服母源抗MV抗体的抑制作用，并诱导产生可识别该病毒的抗肽抗体。这项研究表明，适当选择的合成肽具有作为疫苗的潜力，在存在母源抗病毒抗体的情况下，其具有免疫原性并能诱导产生与病毒反应的抗体。
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