Peters M, ten Cate J W, Koo L H, Breederveld C
J Pediatr. 1984 Aug;105(2):310-4. doi: 10.1016/s0022-3476(84)80138-9.
Coagulation and fibrinolytic factors were investigated daily in 24 SGA and 26 AGA neonates. The results were correlated with placental form and structure and with hematologic values. In the SGA infants, a higher incidence of placental infarction (P less than 0.01), polycythemia (P less than 0.005), and thrombocytopenia (P less than 0.001) was present. During the first 9 days, the mean antithrombin III level in the AGA group increased from 0.36 to 0.53 U/ml, whereas in SGA neonates this value was initially significantly lower (0.27 U/ml) and remained at that level for the entire observation period. The same pattern was found for alpha 2-antiplasmin. The persistent AT-III deficiency and reduced blood flow associated with polycythemia may explain the increased risk of thromboembolic complications in SGA infants described by others.
对24例小于胎龄儿（SGA）和26例适于胎龄儿（AGA）新生儿每日进行凝血和纤溶因子研究。结果与胎盘形态结构及血液学指标相关。SGA婴儿中，胎盘梗死（P<0.01）、红细胞增多症（P<0.005）和血小板减少症（P<0.001）的发生率较高。在出生后的前9天，AGA组抗凝血酶III平均水平从0.36 U/ml升至0.53 U/ml，而SGA新生儿该值最初显著较低（0.27 U/ml），且在整个观察期维持该水平。α2-抗纤溶酶也呈现相同模式。持续的抗凝血酶III缺乏及与红细胞增多症相关的血流减少可能解释了其他人所描述的SGA婴儿血栓栓塞并发症风险增加的原因。
