直肠活检：直肠癌组织学分级的不准确性。
Rectal biopsies: inaccuracy of histological grading in carcinoma of the rectum.
作者信息
Smedley F H, Hoile R W, Macfarlane D A
出版信息
J R Soc Med. 1984 Jul;77(7):564-6. doi: 10.1177/014107688407700708.
In a consecutive series of 70 patients with carcinoma of the rectum, 42 had operable tumours and in these the histology of the initial biopsy was compared with that of the excised specimen. In 9 of the 42 patients the histological grading of the original biopsy was different from that of the final specimen; in 3 the carcinoma was missed despite repeated preoperative biopsies; and in 5, errors were made in the diagnosis of carcinoma in polyps. In 5 of 7 cases of poorly differentiated carcinoma the initial biopsies indicated moderate differentiation: there was therefore a 70% inaccuracy in the preoperative diagnosis of poorly differentiated carcinoma of the rectum. The implications of this inaccuracy for the surgery of rectal cancer are discussed.
在连续的70例直肠癌患者中，42例患有可手术切除的肿瘤，对这些患者的初始活检组织学与切除标本的组织学进行了比较。42例患者中有9例最初活检的组织学分级与最终标本不同；3例尽管术前反复活检仍漏诊癌；5例息肉癌诊断有误。7例低分化癌中有5例初始活检显示为中分化：因此，直肠癌低分化癌术前诊断的不准确率为70%。本文讨论了这种不准确性对直肠癌手术的影响。
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