Halvorsen T B, Seim E
Department of Pathology, Trondheim Regional and University Hospital, Norway.
J Clin Pathol. 1988 May;41(5):532-7. doi: 10.1136/jcp.41.5.532.
Three hundred and sixty eight resected colorectal adenocarcinomas were graded (WHO) retrospectively and the results correlated with estimated length of patient survival. In 30 (82%) of the tumours more than one degree of differentiation was found. Histological grade significantly influenced survival time when other explanatory variables such as tumour site and stage, age, and sex were adjusted for. The results suggested that three degrees of differentiation (well, moderate, and poor) are sufficient for the grading of colorectal carcinomas, and that grading should be based on the predominating degree of differentiation represented in the primary tumour.
对368例切除的结肠直肠癌进行了回顾性WHO分级，并将结果与患者估计生存时间相关联。在30例（82%）肿瘤中发现存在一个以上的分化程度。在对肿瘤部位、分期、年龄和性别等其他解释变量进行校正后，组织学分级对生存时间有显著影响。结果表明，三个分化程度（高分化、中分化和低分化）足以对结肠直肠癌进行分级，且分级应基于原发肿瘤中占主导地位的分化程度。
