Iitsuka Y, Hiraoka H, Kimura A, Kodoh H, Koga S
Jpn J Surg. 1984 May;14(3):207-11. doi: 10.1007/BF02469569.
Cytological examination of exfoliated cells in the bile or irrigated fluid from a percutaneous transhepatic choledochal drainage (PTCD) tube and other jaundice-reducing fistula was performed in 59 patients with obstructive jaundice. Malignant cells were found in 22 of 27 patients with choledochal cancer, 50 of 17 patients with pancreatic cancer, 3 of 6 patients with gallbladder cancer, and one of 5 patients with other malignancies. Exfoliated malignant cells were found at a higher rate in the washed fluid of the PTCD tube than in the pure bile aspirated from the PTCD tube. Half of the positive cases were diagnosed as such upon the first cytological examination, and the remaining in second or subsequent cytological examinations. The cytological appearance of cells in the washed fluid or bile reflected the type of cancer cells found by touch-smear of the lesion and also the histological type. This method requires no special technique and facilitates accurate diagnosis in patients with malignant lesion of the choledochal duct.
对59例梗阻性黄疸患者经皮经肝胆总管引流（PTCD）管及其他减黄瘘管引流的胆汁或冲洗液中的脱落细胞进行了细胞学检查。在27例胆管癌患者中有22例发现恶性细胞，17例胰腺癌患者中有50例，6例胆囊癌患者中有3例，5例其他恶性肿瘤患者中有1例。PTCD管冲洗液中脱落恶性细胞的检出率高于PTCD管吸出的纯胆汁。一半的阳性病例在首次细胞学检查时即被诊断为此病，其余病例在第二次或后续细胞学检查时确诊。冲洗液或胆汁中细胞的细胞学表现反映了病变触片所发现的癌细胞类型以及组织学类型。该方法无需特殊技术，有助于对胆管恶性病变患者进行准确诊断。
