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激素调节的复发性乳腺癌化疗可延长生存期。

Hormone conditioned cancer chemotherapy for recurrent breast cancer prolongs survival.

作者信息

Sugimachi K, Inokuchi K, Matsuura H, Ueo H, Kumashiro R

出版信息

Jpn J Surg. 1984 May;14(3):217-21. doi: 10.1007/BF02469571.

DOI:10.1007/BF02469571
PMID:6748393
Abstract

Left suprarenal-inferior mesenteric venous shunt (Inokuchi) was prescribed for 80 patients with recurrent breast cancer and the efficacy of hormone conditioned cancer chemotherapy was assessed. The patients were separated into 3 groups according to the historical regimen of combined chemotherapy: Group I; surgical hormone therapy alone, Group II; surgery plus short term chemotherapy, and Group III; surgery plus long term chemotherapy. The 5 year survival rate of the responsive patients to the surgical hormone therapy was as high as 84.6 per cent in Group III, as compared to that of Groups I and II, 41.7 per cent and 16.7, respectively. Survival was not prolonged in non-responsive patients, regardless of the group. These findings indicate that surgical hormone therapy combined with postoperative long term cancer chemotherapy is a valid and effective method for treating recurrence of breast cancer.

摘要

对80例复发性乳腺癌患者采用左肾上腺-肠系膜下静脉分流术(井口术式),并评估激素调节性癌症化疗的疗效。根据联合化疗的既往方案将患者分为3组:第一组;单纯手术激素治疗,第二组;手术加短期化疗,第三组;手术加长期化疗。与第一组和第二组分别为41.7%和16.7%相比,第三组中对手术激素治疗有反应的患者5年生存率高达84.6%。无论在哪一组,无反应的患者生存期均未延长。这些发现表明,手术激素治疗联合术后长期癌症化疗是治疗乳腺癌复发的一种有效方法。

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本文引用的文献

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Inhibition of human mammary and prostatic cancers by adrenalectomy.肾上腺切除术对人类乳腺癌和前列腺癌的抑制作用。
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A GENERALIZED WILCOXON TEST FOR COMPARING ARBITRARILY SINGLY-CENSORED SAMPLES.一种用于比较任意单删失样本的广义威尔科克森检验。
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Hormone conditioned cancer chemotherapy for advanced breast cancer with special references to biological significance of adrenal gland.激素调节的晚期乳腺癌化疗——特别论及肾上腺的生物学意义
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Follow-up study of left suprarenal to inferior mesenteric venous shunt for advanced breast cancer.左肾上腺至肠系膜下静脉分流术治疗晚期乳腺癌的随访研究
Br J Surg. 1976 Aug;63(8):639-42. doi: 10.1002/bjs.1800630820.
9
Role of bilateral adrenalectomy (and oophorectomy) in the management of patients with metastatic breast cancer.双侧肾上腺切除术(及卵巢切除术)在转移性乳腺癌患者治疗中的作用。
Am J Surg. 1979 May;137(5):629-33. doi: 10.1016/0002-9610(79)90036-9.