Inokuchi K, Nomura Y, Ikejiri T, Kaibara N
Br J Surg. 1976 Aug;63(8):639-42. doi: 10.1002/bjs.1800630820.
Major endocrine ablation therapy was carried out in 133 patients with advanced breast cancer. Of 40 patients undergoing left suprarenal to inferior mesenteric venous shunt with bilateral oophorectomy and right adrenalectomy, 16 cases (40 per cent) had an objective response. The mean postoperative survival of the patients with a positive response, those showing some response and those who failed to respond was 35-8, 26-5 and 8-8 months respectively. Thus, the results of the present procedure are comparable to those of adrenalectomy. No replacement therapy with corticoids was necessary. An increase in the response rate and extension of the survival time can be expected with the addition of postoperative long term maintenance therapy with chemotherapeutic agents and androgens.
对133例晚期乳腺癌患者实施了主要的内分泌消融治疗。在40例行左肾上腺至肠系膜下静脉分流术并双侧卵巢切除术及右肾上腺切除术的患者中，16例（40%）有客观反应。有阳性反应、有一定反应及无反应患者的术后平均生存期分别为35.8个月、26.5个月和8.8个月。因此，本手术的结果与肾上腺切除术的结果相当。无需进行皮质类固醇替代治疗。预计加用化疗药物和雄激素进行术后长期维持治疗可提高反应率并延长生存时间。
