Osteen R T, Fini E, Wilson R E
J Surg Res. 1984 Aug;37(2):139-44. doi: 10.1016/0022-4804(84)90174-4.
Potential synergy between physiologic levels of heat and chemotherapy was investigated in C57BL/6 mice bearing the B16 melanoma. Low levels of hyperthermia alone had no effect on the growth of the primary tumor but augmented the growth delay induced by cyclophosphamide. Although the addition of hyperthermia to chemotherapy and amputation increased the duration of survival and decreased the number of pulmonary metastases, heat did not increase the cure rate of animals with gross or microscopic pulmonary metastases. The incidence of local recurrence was decreased by hyperthermia in animals treated with chemotherapy and incomplete excision of the primary tumor.
在携带B16黑色素瘤的C57BL/6小鼠中研究了生理水平的热与化疗之间的潜在协同作用。单独的低热水平对原发性肿瘤的生长没有影响，但增强了环磷酰胺诱导的生长延迟。尽管在化疗和截肢的基础上加用热疗可增加生存期并减少肺转移灶数量，但热疗并未提高有肉眼或显微镜下肺转移的动物的治愈率。在接受化疗和原发性肿瘤不完全切除的动物中，热疗降低了局部复发率。
