Majewski R A, Domach M M
Biosystems. 1985;18(1):15-22. doi: 10.1016/0303-2647(85)90057-7.
Computer simulation is used to examine the gain, utilization of enzymatic capacity and response time properties of a simple metabolic network consisting of a sequence of irreversible enzyme reactions controlled by non-allosteric feedback inhibition. The latter properties are chosen because interpretation of a metabolic network's structure can be aided by envisioning the network to maximize a single objective such as flux control. However, by examining the properties as a function of the network's operating point (extent of saturation of the first enzymatic reaction) and structural characteristics, it is found that apparent trade-offs occur between definable objectives. It is suggested that greater consideration of the trade-offs that may occur could help generate metabolic network heuristics and facilitate the interpretation of metabolic networks in terms of the functional role they play in the intact organism.
计算机模拟用于研究一个简单代谢网络的增益、酶促能力利用情况和响应时间特性，该网络由一系列受非变构反馈抑制控制的不可逆酶促反应组成。选择后一种特性是因为通过设想网络以最大化单个目标（如通量控制），可以辅助对代谢网络结构的解释。然而，通过将这些特性作为网络工作点（第一个酶促反应的饱和程度）和结构特征的函数进行研究，发现可定义目标之间存在明显的权衡。建议更多地考虑可能出现的权衡有助于生成代谢网络启发式方法，并便于根据代谢网络在完整生物体中所起的功能作用来解释代谢网络。
