Peigen X, Liyi H, Liwei W
J Ethnopharmacol. 1984 May;10(3):275-93. doi: 10.1016/0378-8741(84)90016-3.
This paper deals with an interdisciplinary study covering historic, botanical, phytochemical, pharmacological and clinical aspects of rhubarb and related species, to lay stress on the correlation between plant phylogeny, chemical constituents and purgative activity. It was found that the official rhubarbs were exclusively restricted in the Sect. Palmata, e.g. Rheum palmatum, R. palmatum var. tanguticum, R. officinale; the following criteria may serve as their standard, viz., the presence of sennoside derivatives and rhein, the occurrence of the reduced form of rhein and aloe-emodin, the leaves with any kind of palmate incision. Comprehensive multivariate analyses showed that there is a very close relationship between the leaf incision, existence of sennosides or rhein and purgative activity.
本文涉及一项跨学科研究，涵盖大黄及相关物种的历史、植物学、植物化学、药理学和临床方面，以强调植物系统发育、化学成分与泻下活性之间的相关性。研究发现，法定大黄仅局限于掌叶组，例如掌叶大黄、唐古特大黄、药用大黄；以下标准可作为其标准，即存在番泻苷衍生物和大黄酸，存在还原形式的大黄酸和芦荟大黄素，叶片有任何类型的掌状裂。综合多变量分析表明，叶片裂、番泻苷或大黄酸的存在与泻下活性之间存在非常密切的关系。
