Green J F, Jackman A P
Med Sci Sports Exerc. 1984 Jun;16(3):299-305.
We present a computer simulation of a two-compartment model of the systemic circulation which demonstrates how this model can be used to understand the mechanism(s) for the maximal exercise cardiac output (Q). The model consists of two parallel vascular channels, the splanchnic channel (all blood draining through the hepatic veins) and the peripheral channel (all other vascular beds). The distinguishing characteristic of each channel is the product of its venous compliance and venous resistance. Model parameters for the human circulation were estimated from similar parameters obtained directly from animal experiments. "Exercise" was achieved by decreasing the compliance of both channels to 40% of their initial value and by redistributing the Q such that the fraction of Q perfusing the splanchnic channel fell from 38 to 5%, while that perfusing the peripheral channel (skeletal muscles) increased from 62 to 95%. These combined changes increased Q from 4.4 to 22.0 l X min-1 and suggest that maximal adjustments of the two-compartment model parameters lead to a prediction of a maximal Q that approaches the maximal Q usually obtained by humans during exercise.
我们展示了一个体循环两室模型的计算机模拟，该模拟展示了如何使用这个模型来理解最大运动心输出量（Q）的机制。该模型由两个平行的血管通道组成，即内脏通道（所有血液通过肝静脉引流）和外周通道（所有其他血管床）。每个通道的显著特征是其静脉顺应性和静脉阻力的乘积。人体循环的模型参数是根据直接从动物实验获得的类似参数估算得出的。“运动”是通过将两个通道的顺应性降低至其初始值的40%，并重新分配心输出量来实现的，使得灌注内脏通道的心输出量比例从38%降至5%，而灌注外周通道（骨骼肌）的心输出量比例从62%增加至95%。这些综合变化使心输出量从4.4升/分钟增加至22.0升/分钟，并表明两室模型参数的最大调整导致对最大心输出量的预测，该预测接近人类在运动期间通常获得的最大心输出量。
