Stefanova-Avramova L N, Kozlovskiĭ A G
Mikrobiologiia. 1984 May-Jun;53(3):437-41.
The effect of a carbohydrate component of the medium, trace elements and aeration on biosynthesis of the alkaloids costaclavine and epicostaclavine was studied with Penicillium gorlenkoanum. Alkaloid biosynthesis was shown to depend on the nature of a carbohydrate component: virtually no alkaloids were accumulated in media with glucose and fructose although these were synthesized at a high rate in a medium with mannitol. The quantity of synthesized alkaloids and the dynamics of the biosynthesis depended on carbohydrate concentration. The growth and alkaloid synthesis were influenced by traces of zinc, iron, copper and manganese. A more intensive aeration stimulated biomass accumulation but suppressed alkaloid biosynthesis.
研究了培养基中的碳水化合物成分、微量元素和通气对戈氏青霉生物合成生物碱肋麦角碱和表肋麦角碱的影响。结果表明，生物碱的生物合成取决于碳水化合物成分的性质：在含有葡萄糖和果糖的培养基中几乎不积累生物碱，尽管它们在含有甘露醇的培养基中合成速率很高。合成生物碱的量和生物合成的动力学取决于碳水化合物的浓度。锌、铁、铜和锰的痕量对生长和生物碱合成有影响。更强的通气促进了生物量的积累，但抑制了生物碱的生物合成。
