Kozlovskiĭ A G, Vepritskaia I G, Gaiazova N B
Prikl Biokhim Mikrobiol. 1986 Mar-Apr;22(2):205-10.
The dynamics of production of agroclavine-I and epoxyagroclavine-I, the basic components of the Penicillium sizovae alkaloid fraction, was being studied. The biosynthesis of alkaloids occurs in two stages coinciding in time with the growth phases. The culture studied is shown to have a considerably higher content of extracellular alkaloids than that of the mycelium. When the culture is grown on a medium with mannitol and succinic acid, separate consumption of carbon sources is observed. The alkaloid production in P. sizovae occurs in the presence of high residual concentrations of phosphorus in the medium.
正在研究西佐夫青霉生物碱组分的基本成分——农吉利麦角碱-I和环氧农吉利麦角碱-I的生成动态。生物碱的生物合成分两个阶段进行，在时间上与生长阶段相吻合。研究表明，所研究的培养物中细胞外生物碱的含量比菌丝体中的含量高得多。当培养物在含有甘露醇和琥珀酸的培养基上生长时，可以观察到碳源的分别消耗。西佐夫青霉中的生物碱生成是在培养基中磷残留浓度较高的情况下发生的。
