Berlyne G M, Brown C, Adler A, Feinroth M V, Feinroth M, Hirsch S, Friedman E A
Arch Intern Med. 1981 Sep;141(10):1275-8.
Five adults suffering from nephrotic syndrome were immersed up to the neck in 1.3 m of warm water for four hours. There was a mean weight loss of 2 kg; 1 kg was lost through sweat and 1 kg was lost through urine. Thirty-five millimoles of sodium was excreted in the urine in four hours, 15 times more than on control days. The urine became hypotonic to plasma in the first two hours of immersion. Aldosterone levels did not change on immersion in three patients, but fell from elevated levels in two others. It is concluded that water immersion up to the neck in nephrotic patients warrants further investigation as a therapeutic agent in those cases that are not responding to conventional diuretic therapy.
五名肾病综合征患者颈部以下浸泡在1.3米深的温水中四小时。平均体重减轻2千克；其中1千克通过汗液流失，1千克通过尿液流失。四小时内尿液中排出35毫摩尔钠，是对照日的15倍。浸泡的前两小时尿液相对于血浆变为低渗。三名患者浸泡时醛固酮水平未改变，但另外两名患者的醛固酮水平从升高状态下降。结论是，对于那些对传统利尿疗法无反应的病例，肾病患者颈部以下水浸作为一种治疗手段值得进一步研究。
