Liskiewicz W
Clin Chim Acta. 1982 Aug 4;123(1-2):145-52. doi: 10.1016/0009-8981(82)90123-1.
The presence of 'oligoclonal' IgG in cerebrospinal fluid is increasingly being used as a confirmatory test in the diagnosis of multiple sclerosis. Visual inspection of stained gels following electrophoresis is currently the routine method of analysis. In order to minimise subjective error and increase the sensitivity of this test, a labelled antibody technique for visualising IgG has been developed. The results of tests on cerebrospinal fluid samples from 49 patients with multiple sclerosis suggest that the incidence of 'oligoclonal' bands containing IgG may be very much lower than previously supposed. The implications of this unexpected finding are discussed.
脑脊液中“寡克隆”IgG的存在越来越多地被用作多发性硬化症诊断的确证性检测。目前，电泳后对染色凝胶进行目视检查是常规分析方法。为了将主观误差降至最低并提高该检测的灵敏度，已开发出一种用于可视化IgG的标记抗体技术。对49例多发性硬化症患者脑脊液样本的检测结果表明，含有IgG的“寡克隆”条带的发生率可能比先前认为的要低得多。本文讨论了这一意外发现的意义。
