Grindon A J
Crit Rev Clin Lab Sci. 1982;17(1):51-75. doi: 10.3109/10408368209107032.
Whole blood donation is recognized to be extremely safe, yet there have been reports of serious problems stemming from whole blood donation, and so-called "donor reactions" are regularly seen. While the physiologic causes of the common donor reactions are not completely understood, some effects of whole blood donation (such as transient iron deficiency) are understood but probably not significant. In order to avoid accepting any volunteer donor who might be at risk of a serious reaction, we may have been overly cautious in exclusion of potential donors. The pheresis donor is subjected to potential depletion of the protein or cellular elements being removed, problems caused by the device used for automated pheresis, or problems related to the infusion of potentially toxic substances. Documented benefit to the patient must balance these additional risks.
全血捐献被认为是极其安全的，但仍有全血捐献引发严重问题的报道，而且所谓的“献血者反应”也屡见不鲜。虽然常见献血者反应的生理原因尚未完全明了，但全血捐献的一些影响（如短暂性缺铁）是已知的，不过可能并不严重。为了避免接纳任何可能有严重反应风险的志愿献血者，我们在排除潜在献血者时可能过于谨慎了。单采献血者会面临所采集的蛋白质或细胞成分潜在耗竭的问题、用于自动单采的设备所引发的问题，或者与输注潜在有毒物质相关的问题。已证实对患者的益处必须能平衡这些额外风险。
