Zervou E K, Ziciadis K, Karabini F, Xanthi E, Chrisostomou E, Tzolou A
The Blood Bank of the University Hospital of Ioannina, Ioannina, Greece.
Transfus Med. 2005 Oct;15(5):389-94. doi: 10.1111/j.1365-3148.2005.00600.x.
The aim of the study was to estimate the type, incidence and causes of donor adverse reactions during and after blood donation in a Greek Blood Bank, where medical staff is responsible for donor selection. 12 173 blood donors were studied for adverse reactions. One-hundred and seven (0.87%) donors had a vasovagal reaction during or after blood donation. Donors who gave blood occasionally had a significant greater incidence of reactions compared with volunteer donors (1.15 versus 0.53%) (P < 0.001). There was no significant difference between men and women (0.85 versus 0.95%). First-time donors (1.7 versus 0.68%) and those under 30 years (1.15 versus 0.71%] had a significant greater possibility to have a reaction (P < 0.001). Twenty-two of 107 (20.5%) donors had a syncopal reaction. There was not a causative correlation of haematocrit, haemoglobin, systolic and diastolic blood pressure, pulse rate and weight in women (except weight in men) in developing a reaction. The stressing experience of phlebotomy was the reason for the higher frequency of a reaction. The incidence of reactions in our donors is lower than in other studies, and the possible reason for this is that only physicians are responsible for the selection of donors and trained personnel are careful of them during the donation process.
本研究旨在评估在希腊一家血库中，由医务人员负责献血者筛选时，献血期间及献血后献血者不良反应的类型、发生率及原因。对12173名献血者的不良反应进行了研究。107名（0.87%）献血者在献血期间或献血后出现血管迷走神经反应。偶尔献血者的反应发生率显著高于志愿献血者（1.15%对0.53%）（P<0.001）。男性和女性之间无显著差异（0.85%对0.95%）。首次献血者（1.7%对0.68%）和30岁以下者（1.15%对0.71%）出现反应的可能性显著更高（P<0.001）。107名出现反应的献血者中有22名（20.5%）发生了晕厥反应。在出现反应方面，女性的血细胞比容、血红蛋白、收缩压和舒张压、脉搏率及体重（男性除外）之间不存在因果相关性。静脉穿刺带来的压力体验是反应发生率较高的原因。我们血库中献血者的反应发生率低于其他研究，其可能原因是只有医生负责献血者的筛选，且训练有素的工作人员在献血过程中对他们予以关照。
